Skip to main content
. Author manuscript; available in PMC: 2020 Feb 22.
Published in final edited form as: Menopause. 2019 Jul;26(7):771–780. doi: 10.1097/GME.0000000000001301

Table 3.

Combined effect of risk genotypes of IRS1 rs1801123, IRS1 rs1801278, AKT2 rs3730256, and AKT2 rs7247515, and % calories from SFA/day on colorectal cancer risk

Total Age ≥ 68 years Age < 68 years
na HRb (95% CI) p n HRb (95% CI) p n HRb (95% CI) p
Risk genotypes
1 referent 336 referent 323 0.83 (0.17 – 4.15) 0.825
2+ 8.35 (3.73 – 18.69) < 0.001 2,937 6.62 (2.11 – 20.72) 0.001 2,943 8.47 (2.70 – 26.53) < 0.001
Percent calories from SFA
0 referent 1,760 referent 1,484 1.24 (0.93 – 1.64) 0.145
1 1.33 (1.04 – 1.70) 0.021 1,513 1.30 (0.94 – 1.79) 0.115 1,782 1.67 (1.22 – 2.29) 0.001
Risk genotypes combined with percent calories from SFA
1 referent 185 referent 157 1.51 (0.25 – 9.09) 0.651
2 4.20 (1.73 – 10.20) 0.002 1,726 4.84 (1.19 – 19.65) 0.027 1,493 5.76 (1.42 – 23.41) 0.014
3 6.85 (2.79 – 16.84) < 0.001 1,362 7.42 (1.81 – 30.43) 0.005 1,616 9.77 (2.39 – 39.99) 0.002

CI, confidence interval; HR, hazard ratio; SFA, saturated fatty acids. Numbers in bold face are statistically significant.

a

The number of risk genotypes (IRS1 rs1801123 TC + TT, IRS1 rs1801278 CC, AKT2 rs3730256 AA, and AKT2 rs7247515 TT) defined as 1 (any individual risk genotype) and 2 (2 or more risk genotypes); the number of % calories from SFA/day defined as 0 (< 11%) and 1 (≥ 11%); the number of combined risk genotypes and % calories from SFA/day defined as 1 (any individual risk genotype with low consumption of SFA/day [< 11%]), 2 (either 2 or more risk genotypes or high consumption of SFA/day [≥ 11%]), and 3 (both 2 or more risk genotypes and high consumption of SFA/day [≥ 11%]).

b

Multivariate regression was adjusted by age (in total analysis), education, marital status, family income, depressive symptom, dietary alcohol/day, dietary fiber/day, % calories from protein/day, % calories from saturated fatty acids/day (in risk genotype analysis), % calories from monounsaturated fatty acids/day, % calories from polyunsaturated fatty acids/day, hypertension ever, cardiovascular disease ever, physical activity, number of cigarettes/day, height, body mass index, waist-to-hip ratio, age at menopause, number of pregnancies, and exogenous (unopposed and opposed) estrogen use.