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. Author manuscript; available in PMC: 2021 Feb 20.
Published in final edited form as: Cell Chem Biol. 2019 Nov 13;27(2):197–205.e6. doi: 10.1016/j.chembiol.2019.10.012

Figure 4 |. OSU-03012 and TAK-632 bind DHODH.

Figure 4 |

(A,B) Crystal Structure of DHODH with compounds OSU-03012 (A) or TAK-632 (B). 2mFo-DFc electron density for OSU-03012 (carbons in yellow) or TAK-632 (carbons in green) contoured at 1 σ. Dashed black lines represent hydrogen bonds between DHODH and its ligands. Interacting residues as predicted by LigPlot+ are shown and labeled.