Figure 4: CRPS does not alter alcohol intake.

A) Baseline ethanol intake by weight shows a sex difference between ethanol consumption (p < 0.0001), with females consuming more ethanol by weight than males regardless of chronic repeated predatory stress (CRPS) history. B) There were no baseline difference in ethanol preference in terms of sex or CRPS history. C) Total fluid intake shows a steady intake of fluid over time (p < 0.0001) as well as a significant sex difference with females consuming more total fluid than males (p < 0.0001). D) Males with a history of CRPS consumed more quinine adulterated ethanol than male controls. Within females, there was no significant difference in quinine adulterated ethanol consumption between the CRPS backgrounds. E) Males with a history of CRPS had a higher quinine adulterated 20% ethanol preference than control males. Control males significantly decreased quinine adulterated ethanol consumption at 100mg/L quinine; whereas, males with a history of CRPS significantly decreased at 200mg/L quinine adulterated ethanol. Within females, there was no significant difference in quinine adulterated ethanol preference between the controls and mice with a history of CRPS. F) Total fluid intake displays a significant effect of sex (p < 0.0001) and time (p < 0.0001). An interaction between time and sex show that females consumed more total fluid on average than males at baseline, 5mg/L, 150mg/L, and 200mg/L quinine. Reported values depict mean ± SEM. #p = 0.06, *p < 0.05, **p < 0.01, ****p < 0.0001.