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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Curr Opin Cell Biol. 2019 Sep 8;62:26–30. doi: 10.1016/j.ceb.2019.07.016

Figure 2: The mechanism of Mammalian polarity proteins in tumorigenesis.

Figure 2:

PAR3 (red), DLG5 (blue) and SCRIB (green) usually function as tumor suppressors, preventing tumorigenesis via regulation of the RAC, HIPPO and MAPK/ERK pathways. LLG2 (purple) and APKCζ (orange) are tumor promoters. LLG2 promotes hyperproliferation via the amino acid transport pathway and aPKCζ can promote metastasis via NFκB signaling.