Table 2.
Effect of intravenous hydrocortisone on [11C]NOP-1A VT
| Regions | [11C]NOP-1A VT | ΔVT (%) | p-values | |
|---|---|---|---|---|
| Baseline condition | Post-hydrocortisone condition | |||
| Amygdala | 16.3 ± 1.9 | 18.7 ± 2.8 | 16.0 ± 21.2 | 0.0046 |
| Hippocampus | 11.6 ± 1.3 | 13.3 ± 2.0 | 15.2 ± 20.2 | 0.0047 |
| Midbrain | 9.4 ± 1.0 | 10.6 ± 1.6 | 13.7 ± 17.5 | 0.0035 |
| Ventral Striatum | 15.1 ± 1.7 | 17.1 ± 2.1 | 13.7 ± 17.6 | 0.0041 |
| Caudate | 12.7 ± 1.4 | 14.0 ± 1.9 | 11.4 ± 18.1 | 0.0162 |
| Putamen | 14.3 ± 1.6 | 16.0 ± 2.0 | 13.3 ± 18.4 | 0.0057 |
| Dorsolateral Prefrontal Cortex | 14.4 ± 1.8 | 16.4 ± 2.4 | 14.3 ± 18.7 | 0.0039 |
| Orbital Frontal Cortex | 14.9 ± 1.8 | 17.1 ± 2.6 | 15.6 ± 18.1 | 0.0016 |
| Medial Prefrontal Cortex | 14.3 ± 1.8 | 16.2 ± 2.4 | 14.3 ± 19.3 | 0.0046 |
| Anterior Cingulate Cortex | 14.6 ± 1.7 | 16.6 ± 2.6 | 14.9 ± 18.6 | 0.0030 |
| Cerebellum | 8.2 ± 0.9 | 9.3 ± 1.3 | 13.9 ± 17.3 | 0.0030 |
p-values shown are from the independent paired t-tests not corrected for multiple comparisons. All regional p-values survived the FDR for multiple comparison correction.