Table 3:

Renal Response to Decongestion

	Non-Obese HFpEF (BMI<30) (N=118)	Obese HFpEF (BMI≥30) (N=214)	p-value
Diuretic dose at Randomization, mg/daya	80 (40, 160)	80 (40, 160)	0.39
Length of Stay, Days	5 (3, 8)	6 (4, 8)	0.37
Changes in Renal Function
Change in Creatinine, mg/dl	−0.02 (−0.20, 0.12)	+0.10 (−0.10, 0.30)	<0.001
% Change in Creatinine	−2 (−12, 11)	+6 (−6, 20)	<0.001
Worsening renal function (rise in Cr≥0.3 mg/dl), n (%)	16 (14)	56 (28)	0.008
Worsening renal function (rise in Cr≥0.5 mg/dl), n (%)	0 (0)	17 (9)	0.002
Change in eGFR, mL/min/1.73m2	0.7 (−5.1, 5.4)	−2.6 (−8.6, 2.8)	0.002
% Change in eGFR	2 (−11, 16)	−7 (−19, 7)	<0.001
Estimates of Decongestion
Change in Weight, lb	−6 (−11, −3)	−7 (−14, −2)	0.23
% Change in Weight	−4 (−7, −2)	−3 (−5, −1)	0.04
Change in NT proBNP, pg/ml	−1046 (−2153, −83)	−583 (−1561, −106)	0.16
% Change in NT proBNP	−24 (−43, −6)	−35 (−57, −6)	0.058
Hemodynamic Changes
Change in systolic blood pressure, mmHg	−6 (−20, 6)	−2 (−18, 7)	0.39
Change in mean blood pressure, mmHg	−5 (−15, 3)	−3 (−13, 8)	0.29

Values represent Median (25th–75th) or % unless otherwise specified

^aDose in intravenous furosemide equivalents