Fig. 6.

Effects of 7,8-DHF and ANA-12 on BDNF-TrkB signaling in mPFC and NAc in anhedonia susceptible rats. a Western blot bands of BDNF-TrkB signaling in the mPFC. b BDNF level in the mPFC (F_(3,20) = 119.273, P < 0.001). c proBDNF level in the mPFC (F_(3,20) = 99.914, P < 0.001). d p-TrkB/TrkB ratio in the mPFC (F_(3,20) = 22.731, P < 0.001). e TrkB level in the mPFC (F_(3,20) = 0.340, P = 0.797). f Western blot bands of BDNF-TrkB signaling in the NAc. g BDNF level in the NAc (F_(3,20) = 17.414, P = 0.001). h proBDNF level in the NAc (F_(3,20) = 21.974, P < 0.001). i p-TrkB/TrkB ratio in the NAc (F_(3,20) = 10.828, P = 0.003). j TrkB level in the NAc (F_(3,20) = 0.140, P = 0.933). Data are shown as mean ± S.E.M. (n = 6). BDNF brain-derived neurotrophic factor, mPFC medial prefrontal cortex, NAc nucleus accumbens, N.S. not significant, p-TrkB phosphorylation-tropomyosin-receptor kinase B, proBDNF precursor of BDNF; *P < 0.05, **P < 0.01 or ***P < 0.001