Table 3.

Hazard ratios from univariable and multivariable Cox regression for overall survival and recurrence-free survival for chemotherapy vs no chemotherapy in patients with R0-resected nodal-positive colon carcinoma UICC stage III (n = 40,497). Multivariable survival analyses were performed for both sexes combined, separately for men and women, and adjusted for year of diagnosis, age at diagnosis, tumor localization, grading, and lymph nodes resected. Patients who died within 90 days after diagnosis were excluded

Group	Outcome	Risk Adjustment	p	Hazard ratio	Lower 95%	Upper 95%
Male and female	Overall survival	No, univariable	< 0.001	0.532	0.514	0.552
		Yes, multivariable*	< 0.001	0.746	0.717	0.776
	Recurrence-free survival	No, univariable	< 0.001	0.591	0.571	0.612
		Yes, multivariable	< 0.001	0.806	0.775	0.838
Male	Overall survival ACO	No, univariable	< 0.001	0.564	0.537	0.593
		Yes, multivariable*	< 0.001	0.721	0.684	0.761
	Recurrence-free survival ACO	No, univariable	< 0.001	0.627	0.597	0.659
		Yes, multivariable	< 0.001	0.782	0.742	0.825
Female	Overall survival ACO	No, univariable	< 0.001	0.494	0.470	0.520
		Yes, multivariable*	< 0.001	0.760	0.716	0.805
	Recurrence-free survival ACO	No, univariable	< 0.001	0.550	0.523	0.578
		Yes, multivariable	< 0.001	0.820	0.774	0.869