Table 4.

Hazard ratios from univariable and multivariable Cox regression for overall survival and recurrence-free survival of female versus male patients with a mean follow-up of 7.8 years (median 7.7) in both the overall study cohort and ACO group. Multivariable survival analyses were adjusted for year of diagnosis, age at diagnosis, tumor localization, second tumor, histological type, grading, and UICC stage

Outcome	Risk Adjustment	p	Hazard ratio	Lower 95%	Upper 95%
Overall survival	No, univariable	< 0.001	0.965	0.952	0.978
	Yes, multivariable*	< 0.001	0.853	0.841	0.864
Recurrence-free survival	No, univariable	< 0.001	0.964	0.952	0.977
	Yes, multivariable	< 0.001	0.857	0.845	0.868
Overall survival ACO	No, univariable	< 0.001	0.941	0.923	0.959
	Yes, multivariable*	< 0.001	0.795	0.780	0.811
Recurrence-free survival ACO	No, univariable	< 0.001	0.941	0.923	0.958
	Yes, multivariable	< 0.001	0.802	0.787	0.818