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Reduced metabolic activity by three carbazole alkaloids from MEF against ovarian cancer.
| Ovarian cancer cell lines | IC50 (μM) | ||
|---|---|---|---|
| Mahanine | Mahanimbine | Koenimbine | |
| PA1 | 11 ± 0.2 | 28 ± 0.11 | 51 ± 0.25 |
| OVCAR3 | 32 ± 0.18 | 52 ± 0.05 | 68 ± 0.22 |
Cells were treated separately with mahanimbine and koenimbine for 48 h, and mahanine was used as the control for comparison [8]. IC50 values were compared. These data were derived from three individual experiments, and mean ± SD was indicated.
