Table 4.
Seasonal variation of three markers and antiproliferative activity of MEFWB.
| The month of collection of leaflets | Mahanine (%) | Mahanimbine (%) | Koenimbine (%) | MEFWB IC50 (μg/ml) |
|---|---|---|---|---|
| February | 5 ± 1.5 | 12 ± 1.4 | 15 ± 1.8 | 73.2 ± 0.15 |
| April | 5 ± 1.9 | 11 ± 1.8 | 12 ± 1.2 | 71.0 ± 0.5 |
| May | 6 ± 1.7 | 9 ± 1.5 | 8 ± 0.9 | 68.0 ± 0.14 |
| July | 9 ± 1.6 | 16 ± 1.2 | 8 ± 1.5 | 55.0 ± 0.3 |
| September | 12 ± 1.8 | 18 ± 1.6 | 10 ± 1.1 | 39.0 ± 0.3 |
| December | 14 ± 1.5 | 20 ± 1.6 | 11 ± 1.25 | 37.0 ± 0.2 |
Composition of markers in MEFWB in different seasons and their IC50. These are representative data collected in one year. MEFWB: mahanine-enriched fraction prepared from West Bengal leaflets. These data were derived from three individual experiments, and mean ± SD was indicated.