Table 3.

Figures of merit of the MCR-ALS regression model for the validation set of CHZ, CRZ, HAL, IMP, and PTN.

Parameters	HAL	IMP	CHZ	CRZ	PNT
Accuracy (mean ± SD)a	99.3 ± 1.45	99.8 ± 1.55	99.8 ± 1.13	100.1 ± 1.45	99.9 ± 0.65
Precision repeatability (RSD%)b	1.09	1.32	0.89	0.67	0.78
Intermediate precision (RSD%)c	1.46	1.56	1.13	1.44	0.65
RMSEP	6.56 × 10−2	6.17 × 10−2	1.65 × 10−2	7.81 × 10−2	5.54 × 10−2
SEP	6.34 × 10−2	5.96 × 10−2	1.59 × 10−2	7.54 × 10−2	5.35 × 10−2
Bias	6.96 × 10−3	−1.74 × 10−2	−2.36 × 10−3	2.07 × 10−2	6.74 × 10−3
RE (%)	1.33	1.35	0.75	1.42	0.67
Correlation coefficient (r2)	0.9994	0.9995	0.9997	0.9996	0.9998

^aThe mean and standard deviation for 15 determinations. ^bThe intraday relative standard deviation (n = 3), an average of three different concentration repeated three times within the same day. ^cThe interday relative standard deviation (n = 3), an average of three different concentration repeated three times in three different days. Low concentrations: 1 μg/mL for HAL, IMP, and CRZ, 0.5 μg/mL for CHZ, and 5 μg/mL for PTN. Intermediate concentrations: 5 μg/mL for HAL, IMP, and CRZ, 2.5 μg/mL for CHZ, and 10 μg/mL for PTN. High concentration: 10 μg/mL for HAL, IMP, and CRZ, 5 μg/mL for CHZ, and 20 μg/mL for PTN.