Table 1.

Cohort summary

Characteristics	Mean (sd) among patients with total fluids < 4 L (N = 786)	Mean (sd) among patients with total fluids < 6 L (N = 1241)	Mean (sd) among patients with total fluids < 8 L (N = 1480)	Mean (sd) among patients with total fluids < 10 L (N = 1579)	Mean (sd) among all patients (N = 1639)
Proportion male	0.50	0.54	0.54	0.54	0.54
Mean (sd) MAP (mmHg)	83 (16)	84 (17)	83 (18)	83 (19)	83 (19)
Mean (sd) weight (Kgs)	80 (31)	81 (29)	81 (28)	81 (28)	81 (28)
Mean (sd) age (years)	69 (18)	68 (18)	67 (18)	67 (18)	67 (18)
Mean (sd) SOFA	6.4 (2.8)	6.7 (3.0)	7.0 (3.1)	7.1 (3.2)	7.3 (3.3)
Mean (sd) Cardiovascular SOFA subscore	1.1 (0.8)	1.2 (1.0)	1.3 (1.1)	1.3 (1.1)	1.4 (1.2)
Mean (sd) renal SOFA subscore	2.5 (1.5)	2.4 (1.6)	2.4 (1.5)	2.5 (1.5)	2.5 (1.5)
Mean (sd) CNS SOFA subscore	1.6 (1.4)	1.8 (1.4)	1.8 (1.5)	1.8 (1.5)	1.9 (1.5)
Mean (sd) respiration SOFA subscore	0.5 (1.1)	0.6 (1.1)	0.6 (1.1)	0.6 (1.1)	0.7 (1.2)
Mean (sd) coagulation SOFA subscore	0.4 (0.8)	0.5 (0.8)	0.5 (0.8)	0.5 (0.8)	0.5 (0.8)
Mean (sd) liver SOFA subscore	0.3 (0.7)	0.3 (0.8)	0.4 (0.8)	0.4 (0.8)	0.4 (0.8)
Proportion Caucasian	0.74 (0.4)	0.73 (0.4)	0.73 (0.4)	0.73 (0.4)	0.73 (0.4)
Mean (sd) Elixhauser	2.4 (1.5)	2.4 (1.5)	2.4 (1.5)	2.4 (1.5)	2.4 (1.5)
Mean (sd) GCS (baseline)	12.9 (3.4)	12.4 (3.8)	12.2 (4.0)	12.2 (4.0)	12.2 (4.1)
Mean (sd) pre-ICU fluid volume (L)	1.4 (0.8)	1.8 (1.0)	2.0 (1.1)	2.1 (1.1)	2.1 (1.1)
Proportion with metastatic cancer	0.06	0.06	0.07	0.07	0.06
Proportion with diabetes	0.06	0.06	0.06	0.06	0.06
Proportion starting vasopressors in first 24 h	0.12	0.18	0.22	0.24	0.26
Proportion initiating MV in first 24 h	0.30	0.35	0.36	0.37	0.38

Characteristics of patients in the cohort broken down by cap on total fluids received by the end of the first 24 h in the ICU. SOFA subscores are computed as maxima over the first 24 h, and SOFA is computed as their sum