Fig. 4.

a Mutually exclusive and co-occurring oncogene mutations in human tumors. Mutations were grouped together when the occurred within a given gene. b Mutation co-occurrence in primary and metastatic pairs. c Incidence of co-occurring mutations. Grey indicates no association of mutations (0.5 odds ratio < 2), Pale yellow indicates some tendency toward mutual exclusivity (0.1 < odds ratio < 0.50), dark yellow indicates strong tendency toward mutual exclusivity (0 < odds ratio < 0.1), light blue indicates tendency toward co-occurrence (2 < odds ratio < 10), dark blue indicates strong tendency toward co-occurrence (odds ratio > 10)