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. 2020 Feb 22;13:13. doi: 10.1186/s13045-020-0846-y

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a Morphological comparison of four patients and PDX tumors (representative hematoxylin-eosin (H&E)-stained sections, magnification × 200). HBCx-162: metaplastic carcinoma with abundant chondromyxoid matrix in both patients and PDX tumors; HBCx-165, HBCx-178, HBCx-130: squamous cell metaplastic carcinoma, in both patients and PDXs. b RT-PCR analysis of the expression of EMT genes (SNAIL2, VIM, ACTA2, SPARC, TCF7L2) in TNBC PDXs (n = 48). Fold changes and p values are calculated for the comparison of gene expression in MSL and M PDXs with that in other TNBC subtypes. Arrow down symbol indicates metaplastic type