Table 1.
Top 15 potential shared neoantigens based on TCGA-SKCM cohort. Recurrent mutations observed on TCGA-SKCM cohort. The amino acid (AA) residue changes caused by somatic mutations are highlighted in the (neo) epitopes sequences. The frequency represents the number of samples showing the corresponding mutation
| Gene | AA change | Neoepitope | HLA haplotype | Frequency |
|---|---|---|---|---|
| RAC1 | P29S | FSGEYITV | HLA-A*02:01 | 17/466 |
| KLHDC7A | E635K | HTATVRAKK | HLA-A*11:01 | 12/466 |
| INMT | S212F | YMVGKREFFCV | HLA-A*02:01 | 9/466 |
| CDH6 | S524L | FLFSLAPEAA | HLA-A*02:01 | 8/466 |
| ZBED2 | E157K | GTMALWASQRK | HLA-A*11:01 | 8/466 |
| CRNKL1 | S128F | LQVPLPVPRF | HLA-A*15:01 | 7/466 |
| IL37 | S202L | FLFQPVCKA | HLA-A*02:01 | 7/466 |
| SERPINB3 | E250K | LSMIVLLPNK | HLA-A*11:01 | 6/466 |
| DNAJC5B | E22K | STTGEALYK | HLA-A*11:01 | 6/466 |
| MYO7B | E512K | MSIISLLDK | HLA-A*11:01 | 6/466 |
| MORC1 | E878K | IQNTYMVQYK | HLA-A*11:01 | 6/466 |
| SCN7A | S445F | IEMKKRSPIF | HLA-A*15:01 | 6/466 |
| PSG9 | E404K | KISKSMTVK | HLA-A*11:01 | 6/466 |
| RAC1 | P29L | FLGEYIPTV | HLA-A*02:01 | 5/466 |
| NUTF2 | Q20K | SSFIQHYYK | HLA-A*11:01 | 5/466 |