Table 2. Prescriptions of hepatotoxic drugs in patients with acute liver failure (n= 4621 patients) compared with the general population*1.
| Hepatotoxic drug | Patients with ALF *3 | General population*4 | Comparison with general population | |||
| (n) | (% of all) | (n) | (% of all) | (%) | (p) | |
| Painkillers | ||||||
| Ibuprofen*2 | 310 | 6.7 | 7 145 928 | 8.7 | -1.97 | <0.001 |
| Diclofenac | 77 | 1.7 | 2 177 394 | 2.6 | -0.98 | <0.001 |
| Acetaminophen*2 | 34 | 0.7 | 991 534 | 1.2 | -0.47 | 0.017 |
| Antibiotics | ||||||
| Amoxicillin | 122 | 2.6 | 2 035 862 | 2.5 | 0.17 | 0.481 |
| Ciprofloxacin | 139 | 3.0 | 1 031 971 | 1.3 | 1.76 | <0.001 |
| Trimethoprim/sulfamethoxazole | 71 | 1.5 | 405 784 | 0.5 | 1.04 | <0.001 |
| Levofloxacin | 39 | 0.8 | 289 716 | 0.4 | 0.48 | <0.001 |
| Nitrofurantoin | 16 | 0.3 | 114 144 | 0.1 | 0.21 | 0.002 |
| Others | ||||||
| Phenprocoumon | 67 | 1.5 | 829 865 | 1.0 | 0.45 | 0.006 |
| Carbamazepine | 7 | 0.1 | 207 871 | 0.3 | -0.11 | 0.221 |
| Cytostatic preparations | 87 | 1.9 | 101 846 | 0.1 | 1.77 | <0.001 |
| All | 4621 | 82 341 288 | ||||
ALF – acute liver failure
*1 Comparison performed using a two-sided binominal test.
*2 Prescriptions only. Over-the-counter-medications are not included.
*3 Number of ALF patients with at least one prescription in the 3 months before coding of ALF
*4 The numbers of patients with at least one prescription were recorded for every quarter during the study period. The average numbers of patients per quarter are presented.