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. 2019 Nov 30;9(3):485–506. doi: 10.1016/j.jcmgh.2019.11.012

Figure 6.

Figure 6

IBD patients have reduced proportions of flagellin-specific CD4+T cells with a Th17 cell surface phenotype. (A) Data from all subjects in cohort 3 (n = 20 each of healthy controls, CD patients, and UC patients) were combined to assess differences in Th1, Th17, and Th17.1 cell proportions within CD4+ T-cell responses to SEB, Pediacel, FliC, and Fla2 antigens (pie charts show mean responses). (B) Data in panel A were analyzed to determine differences between healthy controls (Healthy), CD patients, and UC patients for the proportions of Th1, Th2, Th17, and Th17.1 cells within all antigen-specific CD4+ T-cell responses measured. (C) Unstimulated whole blood for cohort 3 (n = 20 each for healthy controls, CD patients, and UC patients) was analyzed for the frequency of CD4+ T cells (percentage of lymphocytes, n = 20 each) and Th1, Th17, and Th17.1 cells (percentage of CD4+ cells). Statistical tests used were as follows: (A) Friedman test and (B and C) Kruskal–Wallis test; the n for analysis of each parameter not specified here is provided in Table 5. Ag, antigen.