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. 2019 Nov 30;9(3):485–506. doi: 10.1016/j.jcmgh.2019.11.012

Figure 8.

Figure 8

Correlation of fecal microbiome composition with antiflagellin immune responses. (A) Nonmetric multidimensional scaling (MDS1 and MDS2) ordination plot from analysis of β-diversity within 16S rDNA samples for healthy controls, CD patients, and UC patients in cohort 3 (n = 13 each). Adonis multivariate analysis identified that both UC and CD patient groups clustered significantly distinctly from healthy controls (P = .035). Bacteria are shown that were significantly differently abundant in (B) CD patients and (C) UC patients compared with healthy controls. (B and C) Multiple dots indicate detection of >1 sequence for the bacterial genus. (D) Comparison of Shannon’s diversity (H’) index between groups (Kruskal–Wallis test). Spearman (r) correlation between Shannon’s diversity (H’) index and (E) immune responses in patients and healthy controls (n = 39) and (F) Harvey–Bradshaw index for UC and CD patients (n = 26). (G) Heat map showing Spearman correlation analyses between the relative abundance of differentially expressed bacteria and antiflagellin immune responses.