Table 4.

Physical Stability of NIMO-TNE Following Dilution to 0.04 mg/mL in 5% Glucose

Time(h)	Particle Size (nm)	PDI	pH	Content (%)
0	240.23 ± 1.97	0.09 ± 0.03	4.57 ± 0.06	100*
2	238.17 ± 0.84	0.06 ± 0.03	4.62 ± 0.03	100.33 ± 0.37
4	239.80 ± 2.79	0.09 ± 0.02	4.61 ± 0.05	99.91 ± 0.16
6	237.63 ± 3.48	0.08 ± 0.02	4.62 ± 0.04	100.81 ± 1.04
8	239.73 ± 2.54	0.10 ± 0.02	4.65 ± 0.04	100.49 ± 0.40
10	237.23 ± 2.96	0.08 ± 0.02	4.70 ± 0.01	100.30 ± 0.74
12	236.10 ± 1.77	0.09 ± 0.03	4.71 ± 0.05	99.36 ± 0.76
24	238.93 ± 3.18	0.08 ± 0.02	4.83 ± 0.04	99.28 ± 0.16

Notes: All the results are represented as mean ± SD (n=3). *Drug content at 0 h was set to 100% and NIMO content at the remaining time points was expressed as the ratio of drug content at each time point to drug content at 0 h.

Abbreviations: NIMO-TNE, two-vial formulation of nimodipine-loaded nanoemulsion; PDI, polydispersity index.