Table 5.

Physical Stability of NIMO-TNE Following Dilution to 0.04 mg/mL in 0.9% Sodium Chloride

Time (h)	Particle Size (nm)	PDI	pH	Content (%)
0	227.50 ± 1.63	0.05 ± 0.03	5.89 ± 0.08	100*
2	227.10 ± 1.04	0.06 ± 0.03	5.92 ± 0.04	100.74 ± 0.48
4	232.27 ± 3.64	0.06 ± 0.04	5.96 ± 0.05	99.33 ± 0.41
6	228.60 ± 3.72	0.06 ± 0.03	5.94 ± 0.04	100.53 ± 0.06
8	232.80 ± 1.14	0.04 ± 0.01	5.95 ± 0.03	99.31 ± 0.74
10	231.00 ± 0.99	0.05 ± 0.02	6.01 ± 0.03	100.54 ± 0.89
12	231.73 ± 1.61	0.05 ± 0.02	5.96 ± 0.01	99.36 ± 0.76
24	233.00 ± 3.28	0.03 ± 0.02	5.96 ± 0.03	97.34 ± 0.84

Notes: All the results are represented as mean ± SD (n=3). *Drug content at 0 h was set to 100% and NIMO content at the remaining time points was expressed as the ratio of drug content at each time point to drug content at 0 h.

Abbreviations: NIMO-TNE, two-vial formulation of nimodipine-loaded nanoemulsion; PDI, polydispersity index.