Table 6.
Pharmacokinetic Parameters of Nimotop Injection and NIMO-TNE in Rats
| Parameters | Unit | Nimotop | NIMO-TNE |
|---|---|---|---|
| AUC (0-t) | mg/L·min | 20.208 ± 1.514 | 21.031 ± 3.179 |
| AUC (0-∞) | mg/L·min | 20.296 ± 1.577 | 21.120 ± 3.262 |
| MRT (0-t) | min | 38.767 ± 3.170 | 38.795 ± 2.760 |
| MRT (0-∞) | min | 39.814 ± 3.246 | 40.702 ± 4.433 |
| t1/2z | min | 30.753 ± 4.527 | 30.299 ± 4.959 |
| CLz | L/min/kg | 0.040 ± 0.003 | 0.039 ± 0.006 |
Note: All results are presented as means ± SD (n=6).
Abbreviations: NIMO-TNE, two-vial formulation of nimodipine-loaded nanoemulsion; AUC, area under the plasma level time curve; MRT, mean residence time.