Table 3. Complication and outcome of leukocyte adhesion deficiency type I (LAD-I) patients after umbilical cord blood transplantation (UCBT).
| Patient | Engraftment | Chimerism | Neutrophil engraftment day | Platelet engraftment day | GvHD | Complication | WBC/ANC (×109/L) on +100 day | Leukocyte CD18 expression | Outcome (months) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Engrafted | CDC | 28 | 56 | IV | CMV viremia, Bronchiolitis obliterans | 6.4/1.3 | 98.0% | Survived (38 months) |
| 2 | Engrafted | CDC | 13 | 33 | II | – | 6.1/4.1 | 98.8% | Survived (31 months) |
| 3 | Engrafted | CDC | 19 | 36 | – | – | 3.8/0.9 | 96.4% | Survived (19 months) |
| 4 | Engrafted | CDC | 22 | 32 | III | Sepsis, pneumonia, Bronchiolitis obliterans | 5.8/3.8 | 95.2% | Died (8 months) |
| 5 | Engrafted | CDC | 20 | 38 | II | Sepsis, CMV viremia | 3.0/1.3 | 97.6% | Survived (15 months) |
GvHD, graft-versus-host disease; WBC, white blood cell; ANC, absolute neutrophil count; CDC, complete donor chimerism; CMV, cytomegalovirus.