TABLE 3.
Cognitive, Behavioral, and Motor Symptoms at Last Visit Among Those With and Without LATE-NC
| Symptom, Most Recent Visit † | CDR = 0 |
CDR = 0.5 |
CDR = 1, 2, or 3 |
|||
|---|---|---|---|---|---|---|
| LATE-NC n = 7 | No LATE-NC n = 59 | LATE-NC n = 25 | No LATE-NC n = 78 | LATE-NC n = 221 | No LATE-NC n = 226 | |
| Cognitive | ||||||
| Memory | 0 (0.0%) | 2 (3.4%) | 24 (96.0%) | 65 (83.3%) | 220 (99.6%) | 225 (99.6%) |
| Orientation | 0 (0.0%) | 0 (0.0%) | 1 (12.5%) | 7 (22.6%) | 89 (97.8%)** | 85 (92.4%) |
| Executive function | 0 (0.0%) | 3 (5.1%) | 18 (72.0%) | 42 (53.9%) | 216 (99.1%) | 221 (98.7%) |
| Language | 0 (0.0%) | 0 (0.0%) | 11 (44.0%) | 23 (29.5%) | 172 (79.6%) | 186 (83.0%) |
| Visuospatial function | 0 (0.0%) | 0 (0.0%) | 2 (8.0%) | 8 (10.4%) | 151 (70.6%) | 159 (72.9%) |
| Attention/concentration | 0 (0.0%) | 1 (1.7%) | 7 (28.0%) | 10 (13.0%) | 144 (66.7%) | 155 (72.1%) |
| Fluctuating cognition | 0 (0.0%) | 0 (0.0%) | 1 (4.2%) | 2 (2.9%) | 36 (17.6%) | 52 (25.4%) |
| Behavioral | ||||||
| Apathy/withdrawal | 0 (0.0%) | 0 (0.0%) | 6 (25.0%) | 12 (15.6%) | 114 (51.8%) | 129 (57.6%) |
| Depressed mood | 0 (0.0%) | 1 (1.7%) | 11 (44.0%)* | 18 (23.1%) | 63 (29.2%) | 72 (32.7%) |
| Visual hallucinations | 0 (0.0%) | 0 (0.0%) | 1 (4.4%) | 4 (5.2%) | 21 (9.7%)** | 44 (20.4%) |
| Auditory hallucinations | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 2 (2.6%) | 3 (1.4%)** | 20 (9.4%) |
| Delusional beliefs | 0 (0.0%) | 0 (0.0%) | 1 (4.4%) | 2 (2.6%) | 42 (19.4%) | 48 (22.3%) |
| Disinhibition | 0 (0.0%) | 0 (0.0%) | 1 (4.2%) | 10 (13.0%) | 44 (20.3%) | 54 (24.4%) |
| Irritability | 0 (0.0%) | 0 (0.0%) | 4 (16.7%) | 15 (19.5%) | 75 (34.3%) | 75 (34.1%) |
| Agitation | 0 (0.0%) | 0 (0.0%) | 2 (8.3%) | 6 (7.9%) | 58 (26.5%) | 54 (24.2%) |
| Personality change | 0 (0.0%) | 1 (1.7%) | 1 (4.2%) | 2 (2.6%) | 29 (13.4%) | 36 (16.2%) |
| RBD | 0 (0.0%) | 0 (0.0%) | 2 (10.0%) | 1 (2.0%) | 10 (5.6%) | 15 (7.7%) |
| Anxiety | 0 (0.0%) | 1 (3.5%) | 2 (28.6%) | 4 (12.9%) | 25 (27.2%) | 32 (36.4%) |
| Motor | ||||||
| Gait disorder | 0 (0.0%) | 5 (8.5%) | 4 (16.7%) | 18 (23.7%) | 96 (44.9%)** | 121 (55.3%) |
| Falls | 0 (0.0%) | 2 (3.4%) | 3 (12.5%) | 13 (16.7%) | 47 (22.2%)** | 76 (35.7%) |
| Tremor | 0 (0.0%) | 3 (5.1%) | 5 (20.0%) | 11 (14.1%) | 42 (20.1%)** | 61 (28.9%) |
| Slowness | 0 (0.0%) | 3 (5.1%) | 8 (32.0%) | 18 (23.4%) | 105 (49.1%) | 121 (57.6%) |
Abbreviations: LATE-NC, limbic predominant age-related TDP-43 encephalopathy neuropathological change; RBD, Rapid eye movement sleep behavior disorder.
p < 0.05, versus no LATE-NC and CDR = 0.5.
**p < 0.05 versus no LATE-NC and CDR = 1–3 (chi-square/exact tests).
†Missing data, LATE-NC: orientation, n = 150; executive function, n = 3; language, n = 5; visuospatial function, n = 7; attention, n = 5; fluctuating cognition, n = 24; apathy, n = 2; depressed mood, n = 5; visual hallucinations, n = 6; auditory hallucinations, n = 6; delusions, n = 7; disinhibition, n = 5; irritability, n = 3; agitation, n = 3; personality change, n = 6; RBD, n = 53; anxiety, n = 150; gait, n = 8; falls, n = 10; tremor, n = 12; slowness, n = 7; Missing data, LATE-NC: orientation, n = 211; executive function, n = 2; language, n = 2; visuospatial function, n = 9; attention, n = 12; fluctuating cognition, n = 84; apathy, n = 3; depressed mood, n = 6; visual hallucinations, n = 11; auditory hallucinations, n = 14; delusions, n = 12; disinhibition, n = 6; irritability, n = 7; agitation, n = 5; personality change, n = 6; RBD, n = 115; anxiety, n = 215; gait, n = 9; falls, n = 13; tremor, n = 15; slowness, n = 17.