TABLE.
Comparison of Patients With Speech and Language Impairment and FTLD-TDP Type B Pathology
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | |
|---|---|---|---|---|
| Sex | Male | Male | Male | Male |
| Handedness | Right | Right | Right | Right |
| Age at onset (years) | 59 | 64 | 60 | 51 |
| Duration of isolated aphasia/AoS (years) | 4 | 2 | 2 | 3 |
| Presenting clinical features | ||||
| Language | Anomia | Anomia | Syntactic incomprehension | Anomia |
| Speech | None | None | AoS | AoS |
| Motor | None | None | None | None |
| Late clinical features (years after presentation) | ||||
| Language | Agrammatism (2) | No additional features | Agrammatism (1) | Agrammatism (3) |
| Speech | None | Dysarthria (2) | Dysarthria (1) | Anarthria (3) |
| Motor | None | Axial rigidity, SNO (4) | Axial rigidity, SNO (2) | SNO (3) |
| Atrophy | Severe left ATL | Severe left ATL | Left hemisphere | Left hemisphere |
| TDP pathology (granular CI) | L>R STG | IFG, ATL | L>R MFG, IPL | L>R parietal |
| R>L STG | ||||
| ALS pathology | ||||
| UMN | Sparse | Moderate | Frequent | Frequent |
| LMN | Moderate | Sparse | Frequent | Moderate |
AoS, apraxia of speech; ATL, anterior temporal lobe; STG, superior temporal gyrus; MFG, middle frontal gyrus; IFG, inferior frontal gyrus; IPL, inferior parietal lobule; CI, cytoplasmic inclusions; UMN, upper motor neuron; LMN, lower motor neuron.