FIGURE 1.

Representative tau pathology in corticobasal degeneration (CBD) (A–C) and progressive supranuclear palsy (PSP) (D–F). Tauopathy in CBD includes neuronal tau and astrocytic plaques in the frontal cortex (A), neuronal inclusions in the granular cells of the hippocampal dentate gyrus (B), and globose tangles affecting the substantia nigra (C). PSP pathology was frequently neuronal inclusions and tufted astrocytes in the thalamus (D); both tufted astrocytes and oligodendrocytic coiled bodies are present in the frontal cortex (E); the astrocytic and neuronal tau pathology affect the dentate nucleus of the cerebellum with oligodendrocytic coiled bodies common in the surrounding white matter (F). Scale bar in (F) is used in all 160× images. All images are PHF1 immunohistochemistry.