TABLE 7.
Clinicopathological Groups
| Clinical |
CBS |
FTD |
RS |
P |
|||
|---|---|---|---|---|---|---|---|
| FTLD-Tau | CBD | PSP | CBD | PSP | CBD | PSP | PSP |
| Demographics | |||||||
| n | 16 | 11 | 19 | 23 | 10 | 63 | 11 |
| % Male | 31 | 38 | 37 | 91 | 50 | 52 | 82 |
| Age of onset | 67 | 71 | 61 | 69 | 58 | 68 | 68 |
| Duration | 5.6 | 6.1 | 6.4 | 6.0 | 4.4 | 7.0 | 10.7 |
| Age at death | 71 | 77 | 67 | 75 | 62 | 75 | 80 |
| Pathology | |||||||
| FTD-Tau | 86.9 | 74.0 | 95.5 | 71.9 | 92.5 | 68.9 | 46.4 |
| NFT (%) | 63 | 85 | 53 | 74 | 30 | 73 | 64 |
| AB (%) | 44 | 77 | 47 | 65 | 30 | 59 | 73 |
| LB (%) | 6 | 15 | 11 | 22 | 10 | 11 | 18 |
| TDP-43 (%) | 31 | 8 | 26 | 17 | 50 | 10 | 36 |
| Deficits (%) | |||||||
| Behavioral | 18 | 36 | 53 | 59 | 67 | 48 | 9 |
| Executive | 91 | 64 | 73 | 68 | 89 | 41 | 9 |
| Language | 64 | 64 | 100 | 68 | 56 | 52 | 0 |
| Memory | 45 | 27 | 47 | 50 | 56 | 28 | 18 |
| Motor | 91 | 91 | 33 | 59 | 100 | 72 | 27 |
| Visuospatial | 64 | 36 | 60 | 27 | 67 | 30 | 0 |
| Genetics (%) | |||||||
| ApoE e2 | 13 | 23 | 26 | 9 | 10 | 21 | 27 |
| ApoE e4 | 19 | 15 | 16 | 22 | 0 | 19 | 18 |
| MAPT H1H1 | 81 | 77 | 84 | 91 | 70 | 95 | 82 |
| MAPT H1c 2 alleles | 19 | 64 | 16 | 35 | 20 | 29 | 18 |