Figure 7.

Summary diagram. T39 ASO and mRNA target form a double-stranded sequence that is recognized and degraded by RNase-H-mediated degradation. Our data suggest that some product of this triggers the induction of an anti-viral type I IFN response, which induces Ifnβ expression. IFNβ is released from the cell and can act in an autocrine or paracrine manner by binding to IFNAR1/2 and inducing the expression of IFN-stimulated genes (ISGs) such as Ifit1 and Ifit3. Within the adipocyte, this can trigger browning of white adipose tissue and lipolysis via still unknown mechanisms. This figure was created with BioRender.com.