Table 1.

The studies characteristics included in the final stage of the appraisal.

First author name	Year	Sample size in case group (>6 cyle TMZ)	Sample size in control group (6 cyle TMZ)	OS in case group (>6 cyle TMZ)	OS in control group (6 cyle TMZ)	PFS in case group (>6 cyle TMZ)	PFS in control group (6 cyle TMZ)
Bhandari	2017	20	20	23.8	15.4	16.8	12.8
Skardelly	2017	32	32	28.6	25.2	20.9	13.7
Gramatzki et al.	2017	61	81	25.6	26.2	13.5	10.2
Refae et al.	2015	30	29	24.1	18.1	18.8	12.1
Malkoun et al.	2012	29	23	24.6	16.5	24.6	16.5
Barbagallo et al.	2014	19	18	28	8	20	4
Blumenthal et al.	2017	291	333	27	24.9	12.2	10.4