Table 5.
Clinicopathology parameters and tissues collected for histopathology.
| Parameter | Test | Tissues Collected For Histopathology |
|---|---|---|
| Hematology (90-Day study only) |
Red blood cell count | Adrenals1,2,3,4 |
| Red blood cell indices | Brain1 (medulla/pons, cerebellum, cerebral cortex)4 | |
| Hematocrit | Spinal cord (cervical, mid-thoracic, lumbar)4, sciatic nerve4 | |
| Hemoglobin | Epididymies1,2,4 | |
| Platelet count | Testes1,2,4 | |
| White blood cell count | Prostate4 | |
| White blood cell differential count | Seminal vesicles4 | |
| Abnormal morphology | Ovary and oviducts1,2,4 | |
| Clinical chemistry | Prothrombin time | Vagina4, uterus1,4, cervix4 |
| Activated partial thromboplastin time | Mammary gland4 | |
| Aspartate aminotransferase | Heart1,4 | |
| Alanine aminotransferase | Aorta4 | |
| Sorbitol dehydrogenase | Kidneys1,2,3,4 | |
| Alkaline phosphatase | Urinary bladder4 | |
| Urea nitrogen | Pancreases4 | |
| Creatinine (blood) | Liver1,3,5 | |
| Glucose (after 15 hours of fasting) | Esophagus4, stomach4, duodenum, 4 ileum with GULT4,6, jejunum4, colon4, cecum4, rectum4 | |
| Triglycerides | Salivary glands (sublingual, submandibular, parotid)4 | |
| Total protein | Spleen1,4 | |
| Albumin | Thymus1,4 | |
| Globulin | Lymph nodes (mandibular, mesenteric)4 | |
| Phosphorous (inorganic) | Sternum4 | |
| Calcium | Femur4 (bone) | |
| Sodium | Bone marrow (femur and sternum)4 | |
| Potassium | Pituitary gland4 | |
| Chloride | Thyroid4 | |
| Urinalysis | Quality | Parathyroid gland4 |
| Volume | Nose4 | |
| Clarity | Nasal turbinates4 | |
| color | Pharynx4 | |
| pH | Larynx4 | |
| Specific gravity | Trachea4 | |
| Blood | Lungs4 | |
| Glucose | Eyes4 | |
| Protein | Skeletal muscle4 | |
| Ketones | Skin4 | |
| Bilirubin | Harderian gland4 | |
| Urobilinogen | Eye ball4 and optic nerve4 | |
| Microscopic exam (sediment) | Necropsy lesions7 |
1Relative organ weight determined on 90-day study. 2 Combined weight. 3 Histopathology - 14-day study. 4 Histopathology - 90-day study, Groups 1 and 4. 5 All animals in 90-day study. 6 Gut associated lymphoid tissue. 7 All lesions observed during necropsy.