Table 6.
Effect of 90-Day oral administration of test article on hematological parameters in male and female rats (n = 60/sex).
| Parameter | Units | Group and Dose (mg/kg bw/day) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| G1 (0) n = 10 |
G2 (200) n = 10 |
G3 (400) n = 10 |
G4 (800) n = 10 |
G5 (0) n = 5 |
G6 (200) n = 5a |
G7 (400) n = 5 |
G8 (800) n = 5 |
||
| Males | |||||||||
| WBC | x10^3/μL | 12.003 ± 2.5464 | 12.181 ± 2.6785 | 12.824 ± 2.6230 | 12.613 ± 2.4870 | 10.212 ± 1.3324 | 10.746 ± 2.3541 | 10.602 ± 2.1115 | 10.173 ± 2.5306 |
| RBC | x10^6/μL | 9.145 ± 0.2419 | 8.975 ± 0.4785 | 9.063 ± 0.2436 | 9.064 ± 0.3084 | 9.050 ± 0.1869 | 8.966 ± 0.2845 | 8.988 ± 0.4482 | 8.683 ± 0.3308 |
| HGB | g/dL | 15.71 ± 0.415 | 15.48 ± 0.614 | 15.48 ± 0.380 | 15.41 ± 0.567 | 15.06 ± 0.627 | 15.28 ± 0.838 | 15.20 ± 0.515 | 14.85 ± 0.500 |
| HCT | % | 50.76 ± 1.356 | 49.97 ± 2.048 | 49.83 ± 1.443 | 50.28 ± 1.915 | 48.86 ± 2.503 | 50.58 ± 2.359 | 48.64 ± 1.581 | 47.83 ± 0.971 |
| MCV | fL | 55.52 ± 1.316 | 55.96 ± 1.407 | 54.98 ± 0.997 | 55.48 ± 1.576 | 54.36 ± 1.733 | 56.44 ± 1.582 | 54.12 ± 0.983 | 55.13 ± 1.024 |
| MCH | pg | 17.20 ± 0.481 | 17.25 ± 0.635 | 17.10 ± 0.610 | 16.99 ± 0.524 | 16.74 ± 0.586 | 17.06 ± 0.684 | 16.88 ± 0.383 | 17.13 ± 0.287 |
| RDW | % | 13.35 ± 0.698 | 12.65 ± 0.519 | 12.39 ± 0.703 | 12.31 ± 0.576 | 14.22 ± 1.055 | 13.58 ± 1.270 | 13.78 ± 0.841 | 14.40 ± 1.080 |
| PLT | x10³/μL | 1102.2 ± 94.23 | 1086.8 ± 116.78 | 997.0 ± 120.12 | 1115.8 ± 130.17 | 1063.8 ± 64.93 | 1107.4 ± 75.33 | 1090.2 ± 63.05 | 1220.5 ± 90.89 |
| ANEU | x10³/μL | 1.344 ± 0.3022 | 1.670 ± 0.4869 | 1.678 ± 1.0030 | 1.274 ± 0.5797 | 1.612 ± 0.4010 | 1.536 ± 0.7282 | 1.860 ± 0.7529 | 1.795 ± 0.8626 |
| ALYM | x10³/μL | 9.924 ± 2.2637 | 9.812 ± 2.2488 | 10.487 ± 2.6969 | 10.738 ± 2.0499 | 8.074 ± 1.1539 | 8.610 ± 2.0187 | 7.988 ± 1.3494 | 7.975 ± 1.6805 |
| AMON | x10³/μL | 0.236 ± 0.0682 | 0.245 ± 0.0636 | 0.247 ± 0.0638 | 0.222 ± 0.0675 | 0.290 ± 0.0700 | 0.364 ± 0.0934 | 0.290 ± 0.1032 | 0.210 ± 0.0796 |
| AEOS | x10³/μL | 0.135 ± 0.0538 | 0.145 ± 0.0599 | 0.127 ± 0.0403 | 0.113 ± 0.0271 | 0.124 ± 0.0251 | 0.140 ± 0.0255 | 0.142 ± 0.0630 | 0.118 ± 0.0206 |
| ABAS | x10³/μL | 0.157 ± 0.0634 | 0.123 ± 0.0702 | 0.151 ± 0.0692 | 0.115 ± 0.1300 | 0.032 ± 0.0110 | 0.034 ± 0.0195 | 0.072 ± 0.0268 | 0.080 ± 0.0432 |
| ALUC | x10³/μL | 0.210 ± 0.1175 | 0.143 ± 0.0538 | 0.138 ± 0.0563 | 0.150 ± 0.0650 | 0.084 ± 0.0297 | 0.062 ± 0.0249 | 0.060 ± 0.0200 | 0.053 ± 0.0189 |
| ARET | ^10³/μL | 174.64 ± 30.227 | 162.53 ± 21.656 | 154.13 ± 25.008 | 153.24 ± 38.475 | 226.70 ± 49.313 | 208.22 ± 45.992 | 202.16 ± 37.096 | 282.15 ± 78.425 |
| %RET | % | 1.911 ± 0.3349 | 1.815 ± 0.2654 | 1.698 ± 0.2491 | 1.693 ± 0.4258 | 2.506 ± 0.5445 | 2.334 ± 0.5865 | 2.266 ± 0.5042 | 3.278 ± 1.0448 |
| MCHC | g/dL | 30.98 ± 0.469 | 30.84 ± 0.615 | 31.09 ± 0.775 | 30.78 ± 0.294 | 30.84 ± 0.643 | 30.62 ± 0.432 | 31.20 ± 0.442 | 31.05 ± 0.387 |
| Females | |||||||||
| WBC | x10^3/μL | 7.393 ± 3.0714 | 7.684 ± 1.8437 | 9.415 ± 3.2499 | 10.953 ± 4.5153 | 5.458 ± 0.6154 | 8.803+D±2.1248 | 5.794 ± 1.3307 | 7.054 ± 1.5227 |
| RBC | x10^6/μL | 8.494 ± 0.1585 | 8.476 ± 0.4019 | 8.969 ± 0.3346 | 8.564 ± 0.3825 | 8.480 ± 0.3836 | 8.203 ± 0.5986 | 8.426 ± 0.7084 | 8.504 ± 0.3164 |
| HGB | g/dL | 14.93 ± 0.422 | 14.85 ± 0.728 | 15.36 ± 0.497 | 15.01 ± 0.649 | 14.74 ± 0.673 | 14.78 ± 0.695 | 14.60 ± 0.837 | 15.28 ± 0.396 |
| HCT | % | 47.16 ± 1.243 | 47.00 ± 2.552 | 48.82 ± 1.755 | 47.84 ± 2.097 | 47.50 ± 2.437 | 45.73 ± 1.898 | 45.60 ± 3.415 | 47.24 ± 1.135 |
| MCV | fL | 55.52 ± 1.229 | 55.34 ± 1.585 | 54.45 ± 1.252 | 55.87 ± 0.943 | 55.98 ± 0.881 | 55.90 ± 2.578 | 54.18 ± 1.316 | 55.58 ± 1.628 |
| MCH | pg | 17.56 ± 0.395 | 17.48 ± 0.374 | 17.14 ± 0.433 | 17.50 ± 0.269 | 17.42 ± 0.342 | 18.03 ± 0.714 | 17.34 ± 0.627 | 17.96 ± 0.559 |
| RDW | % | 11.44 ± 0.422 | 11.15 ± 0.438 | 11.31 ± 0.574 | 11.13 ± 0.377 | 11.88 ± 0.277 | 11.90 ± 0.891 | 11.96 ± 0.207 | 11.50 ± 0.339 |
| PLT | x10³/μL | 1063.0 ± 115.60 | 1104.7 ± 148.69 | 1136.5 ± 92.72 | 1086.6 ± 140.98 | 1130.2 ± 124.43 | 1132.8 ± 53.38 | 1196.2 ± 184.23 | 1079.0 ± 90.42 |
| ANEU | x10³/μL | 0.777 ± 0.2868 | 0.948 ± 0.4079 | 1.098 ± 0.6354 | 1.041 ± 0.4468 | 1.074 ± 0.1604 | 1.310 ± 0.6002 | 0.808 ± 0.4494 | 1.022 ± 0.3292 |
| ALYM | x10³/μL | 6.117 ± 2.6226 | 6.359 ± 1.4719 | 7.762 ± 2.8518 | 9.198 ± 3.8399 | 4.074 ± 0.5327 | 5.648 ± 2.1077 | 4.526 ± 0.8009 | 5.660 ± 1.5465 |
| AMON | x10³/μL | 0.146 ± 0.0941 | 0.131 ± 0.0453 | 0.187 ± 0.1058 | 0.211 ± 0.1042 | 0.154 ± 0.0503 | 0.248 ± 0.1056 | 0.148 ± 0.0342 | 0.152 ± 0.0476 |
| AEOS | x10³/μL | 0.111 ± 0.0331 | 0.095 ± 0.0443 | 0.145 ± 0.0510 | 0.141 ± 0.0569 | 0.116 ± 0.0451 | 1.045 ± 1.8237 | 0.144 ± 0.0673 | 0.106 ± 0.0313 |
| ABAS | x10³/μL | 0.089 ± 0.0666 | 0.055 ± 0.0276 | 0.111 ± 0.0479 | 0.088 ± 0.0909 | 0.012 ± 0.0084 | 0.068 ± 0.0350 | 0.052 ± 0.0409 | 0.066 ± 0.0182 |
| ALUC | x10³/μL | 0.094 ± 0.0608 | 0.097 ± 0.0365 | 0.119 ± 0.0443 | 0.158 ± 0.1033 | 0.024 ± 0.0114 | 0.508 ± 0.08954 | 0.030 ± 0.0071 | 0.032 ± 0.0130 |
| ARET | ^10³/μL | 144.89 ± 27.439 | 134.71 ± 28.594 | 128.37 ± 35.153 | 117.06 ± 22.355 | 165.06 ± 21.450 | 159.40 ± 18.481 | 156.48 ± 25.886 | 156.76 ± 47.490 |
| 7.%RET | % | 1.706 ± 0.3266 | 1.584 ± 0.3151 | 1.429 ± 0.3741 | 1.372 ± 0.2820 | 1.948 ± 0.2406 | 1.948 ± 0.2105 | 1.848 ± 0.1571 | 1.850 ± 0.5735 |
| MCHC | g/dL | 31.64 ± 0.414 | 31.56 ± 0.392 | 31.49 ± 0.398 | 31.34 ± 0.336 | 31.14 ± 0.508 | 32.30*D±0.497 | 32.02 ± 0.829 | 32.34*D±0.559 |
Values are mean ± standard deviation. ABAS = absolute basophil; AEOS = absolute eosinophil; ALUC = absolute large unstained cell; ALYM = absolute lymphocyte; AMON = absolute monocyte; ANEU = absolute neutrophil (all forms); ARET = absolute reticulocyte; HCT = hematocrit; HGB = hemoglobin; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; MCV = mean corpuscular volume; PLT = platelet count; RBC = red blood cell count; RDW = red cell distribution width; WBC = white blood cell count.
aN=4 for group 6 females.