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. 2020 Feb 24;16(2):e8985. doi: 10.15252/msb.20198985

Figure 7. Model of mechano‐sensing of metabolic status during liver regeneration.

Figure 7

  1. Model of YAP regulation by mechanical stimulation through expansion of the BC. Arrows denote reactions or transport steps. Blue numbers label individual processes and associated parameters as listed in Appendix Table S4. The pathway combines a signaling cascade with regulated cytoplasmic retention and is here illustrated based on inactivation by a mechano‐sensor, SENSOR; inactSENSOR, inactivated mechano‐sensor; inactYAP, inactivated YAP; SF, sequestration factor; but alternative molecular states are possible. See Supplementary Experimental Procedures for model equations and analysis.
  2. Model prediction (solid black line) of cortical tension and strain and nuclear YAP levels reveals a sigmoidal stimulus‐response curve. Experimental data (symbols, shown as mean ± s.e.m.) of nuclear YAP are reproduced from Fig 3D and mapped to cortical tension and strain levels using experimental data from Figs 1B and 2D. For details see legend of Figs 1B, 2D, and 3D.
  3. Schematic drawing of YAP regulation by BA through canalicular cortical tension and strain. Tissue resection by partial hepatectomy induces a BA overload which elevates osmotic pressure and cortical tension of bile canaliculi. Concomitant changes of apical acto‐myosin properties recruit YAP to the apical cortex where it is activated for nuclear translocation.