Table 1.
Clinical Chemistry and Hematology Parameters for ASO/LNP Complex-Treated Mice
| Groups | ALT (U/L) | AST (U/L) | Cr (mg/dL) | BUN (mg/dL) | Spleen (mg) |
|---|---|---|---|---|---|
| 0 mg·kg-1 | 20.24 ± 2.78 | 129.14 ± 17.89 | 0.35 ± 0.09 | 20.28 ± 2.39 | 76.8 ± 3.6 |
| 1 mg·kg-1 | 20.53 ± 2.03 | 131.76 ± 15.88 | 0.35 ± 0.09 | 20.11 ± 3.69 | 77.3 ± 3.1 |
| 3 mg·kg-1 | 17.88 ± 3.38 | 129.95 ± 20.21 | 0.36 ± 0.07 | 20.9 ± 2.51 | 79.7 ± 1.6 |
| 5 mg·kg-1 | 19.84 ± 3.5 | 133.34 ± 15.08 | 0.37 ± 0.1 | 21.99 ± 2.34 | 80.9 ± 2.2 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, creatinine. Data points are expressed as a percentage of saline control animals and represent group mean ± SD (n = 3).