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. 2019 Oct 18;118(4):790–797. doi: 10.1016/j.bpj.2019.10.010

Figure 2.

Figure 2

Cytosolic gate. (a) A view of rEAG channel gate from the cytosol. Residues occluding access to the pore (Q476) are shown as spheres. (b) Superposition of hERG (pink) and rEAG (light green) channels without gate side chains viewed as in (a). Displacement of S6 and S5 helices during gating is suggested by arrows in one subunit. (c) The gate region of superposed hERG and rEAG viewed from the membrane. Displaced S6 and S5 helices around the gate region of the pore domain are indicated. The N-terminal helices of the C-linker are also visible, showing similar displacement of hERG relative to rEAG.