Figure 5.

The Antitumor Effect of Recombinant Adenoviruses In Vivo

(A) Ad-RGD-Survivin-ZD55-miR-143 inhibited the growth of the HCT116 xenograft tumors. Tumor growth curves were plotted, and the xenograft tumor volumes of recombinant virus groups were compared to those of the control group (*p < 0.05; **p < 0.01). (B) All tumors of recombinant viruses and control groups were removed from the nude mice, and images were captured. (C) Representative images of H&E staining (200× magnification), TUNEL staining (400× magnification), and IHC staining of KRAS (400× magnification) were obtained by an inverted microscope. (D) The expression level of KRAS in cell cytoplasm of recombinant virus groups was lower than that in the control group (400× magnification).