Figure 4.

Allosteric coefficients for cooperative binding at Na⁺ and Mg²⁺ binding sites in the simulated MOP receptor systems. (a)–(c) refer to inactive, active with charged D^2.50, and active with neutral D^2.50 MOP receptor, respectively. The coefficients are reported as $\log \alpha$, with negative values (in red) corresponding to negative cooperativity and positive values (blue) corresponding to positive cooperativity of the cation binding affinity. To see this figure in color, go online.