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Sodium Binding to the MOP Receptor
| Kd (MD) | |
|---|---|
| Inactive | |
| D216ECL2/C127ECL2 | 0.50 |
| Orthosteric site | 0.60 |
| Allosteric site | 0.01 |
| Active Charged D2.50 | |
| G1312.67/D216ECL2 | 1.18 |
| Orthosteric site | 0.36 |
| Allosteric site | 1.29 |
| Active Neutral D2.50 | |
| D216ECL2/N1272.63 | 0.62 |
| E310ECL3 | 1.79 |
| Orthosteric site | 3.36 |
Estimates of Na+ binding affinities (in Molar units) to sites sampled by MD.
