Figure 4.

Correlation network analysis. (a) Shown are network centrality values per amino acid, color coded by its value. The vertical lines highlight residues Gly643 and Val679. (b) Shown is three-dimensional molecular structure mapping the consensus network communities and residue couplings, and the community network is depicted with colored spheres whose relative radius indicates the number of residues in a particular community. Different colors are used to indicate different groups of amino acid residues. The linking gray lines show their relative intercommunity coupling. (c) The most likely path of allosteric communication linking the 1-ARD and 2-ARD domains and residues Gly643 and Ile679. The green spheres show the position of the 1-ARD and 2-ARD and the residues at the gate (Ile679) and the selectivity filter (Gly643). To see this figure in color, go online.