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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Bone. 2019 Jun 21;127:199–206. doi: 10.1016/j.bone.2019.06.018

Table 2.

Structural mechanical properties from 3-point bending of the femoral mid-diaphysis.

WT
OIM+/−
Control RAL ZOL RAL + ZOL p-Value Control RAL ZOL RAL + ZOL p-Value
Yield force (N)*# 12.7 ± 1.3 14.7 ± 1.6** 14.3 ± 2* 14.7 ± 1.8** 0.007 11.9 ± 2 14.1 ± 1.7** 13.7 ± 1.8 14.3 ± 2.2** 0.008
Ultimate force (N)*# 17.6 ± 2.4 19.8 ± 2.1 18.8 ± 3.4 20.8 ± 3.1** 0.023 14.8 ± 1.6 16.2 ± 1.6 16.4 ± 2.5 17.4 ± 2.2** 0.011
Displ. to yield (μm) 148.4 ± 30.6 138.5 ± 21.9 148.8 ± 17.3 130.6 ± 12.8 0.092 142.9 ± 18.9 147 ± 12.8 142.1 ± 20.4 142.8 ± 16.1 0.862
Post yield Displ. (μm)* 899.9 ± 417 590.8 ± 291.5 638.9 ± 395.6 539.6 ± 196* 0.029 343.8 ± 177.3 215.7 ± 120.3 261.7 ± 156.5 238.2 ± 100.6 0.096
Total displ. (μm)* 1048.3 ± 421.5 729.3 ± 292.5* 787.8 ± 407.1 670.2 ± 197.6* 0.024 486.6 ± 181.4 362.7 ± 121.6 403.9 ± 152 381 ± 104.3 0.111
Stiffness (N/mm)*# 97.7 ± 18.9 120.1 ± 19.7** 107.9 ± 21.7 125.8 ± 14.5*** <0.001 92.4 ± 9.9 107 ± 14.5* 107.9 ± 17* 111.5 ± 16** 0.006
Work to yield (mJ) 1.02 ± 0.23 1.11 ± 0.23 1.15 ± 0.17 1.05 ± 0.2 0.386 0.93 ± 0.25 1.13 ± 0.19 1.06 ± 0.25 1.12 ± 0.24 0.103
Post yield work (mJ) 11.2 ± 4.29 9.46 ± 4.33 9.36 ± 4.27 9.62 ± 3.52 0.587 4.61 ± 2.49 3.1 ± 1.51 3.97 ± 2.48 3.79 ± 1.69 0.289
Total work (mJ) 12.22 ± 4.22 10.57 ± 4.37 10.51 ± 4.37 10.67 ± 3.6 0.633 5.54 ± 2.55 4.23 ± 1.47 5.03 ± 2.5 4.9 ± 1.82 0.431

Values are presented as mean ± standard deviation. In the property column, a significant main effect of treatment is indicated by ‘*’ in WT and ‘#’ in OIM+/−. A significant difference from control within each genotype is indicated by ‘*’ for p < 0.05, ‘**’ for p < 0.01, and ‘***’ for p < 0.001. Displ. – displacement.