Table 3.

Estimated tissue-level mechanical properties from 3-point bending of the femoral mid-diaphysis.

	WT					OIM+/−
	Control	RAL	ZOL	RAL + ZOL	p-Value	Control	RAL	ZOL	RAL + ZOL	p-Value
Yield stress (MPa)#	143 ± 30.8	161 ± 24.3	167.2 ± 29.5	167.3 ± 33.7	0.104	143.3 ± 24.4	187 ± 42.5**	172.5 ± 35.6*	183.2 ± 17.4**	0.002
Ultimate stress (MPa)*#	194.3 ± 26.7	215.5 ± 20.3	217.7 ± 35.5	236.6 ± 49.3**	0.020	179.3 ± 30.5	213.3 ± 37.1*	205.4 ± 34	224.7 ± 23.3**	0.003
Strain to yield (mε)	22.9 ± 3.9	21.0 ± 3.5	22.7 ± 2.8	20.1 ± 1.9	0.060	21.3 ± 4.1	21.9 ± 2.3	21.4 ± 3.8	21.3 ± 3.3	0.949
Total strain (mε) *	162.3 ± 63.5	113.2 ± 52	119.6 ± 57.2	104.3 ± 33.4*	0.023	72.9 ± 30.1	55 ± 20.5	60.2 ± 21.4	57 ± 16.8	0.162
Modulus (GPa)*	6.92 ± 1.19	8.65 ± 1.6	8.33 ± 2.54	9.39 ± 2.34**	0.013	7.74 ± 2.19	9.69 ± 3.2	9.09 ± 2.11	9.76 ± 1.82	0.106
Resilience (MPa)#	1.8 ± 0.62	1.85 ± 0.49	2.03 ± 0.35	1.83 ± 0.39	0.567	1.64 ± 0.38	2.2 ± 0.43**	2.03 ± 0.69	2.13 ± 0.4*	0.017
Toughness (MPa)	21.3 ± 7.6	17.34 ± 6.27	18.53 ± 7.63	18.28 ± 5.71	0.456	9.66 ± 4.03	8.12 ± 2.68	9.15 ± 3.84	9.23 ± 2.78	0.650

Values are presented as mean ± standard deviation. In the property column, a significant main One-Way ANOVA effect of treatment is indicated by ‘*’ in WT and ‘#’ in OIM+/−. A significant difference from control within each genotype is indicated by ‘*’ for p < 0.05, ‘**’ for p < 0.01, and ‘***’ for p < 0.001.