Figure 2.

The potential applications of melatonin in human reproduction. Since the application of melatonin has antioxidant effects in reproductive medicine, there are two possibilities. One is that in vivo melatonin administration to patients before ovulation may improve the oocyte quality. Another possibility is melatonin supplementation added to in vitro culture media to enhance oocyte maturation, fertilization, and embryonic development. IVF-ET: in vitro fertilization and embryo transfer, ICSI: intra-cytoplasmic sperm injection.