LSDs |
Lysosomal storage disorders |
GAA |
Acid α-glucosidase |
LAMP-2 |
Lysosomal associated membrane protein-2 |
a-Gal A |
Alpha-galactosidase A |
Gb3 |
Globotriaosylceramide |
MPS |
Mucopolysaccharidosis |
GAGs |
Glycosaminoglycans |
TFEB |
Transcription factor EB |
CM |
Cardiomyocyte |
I/R |
Ischemia-reperfusion |
ECM |
Extracellular matrix |
DCM |
Dilated cardiomyopathy |
CHF |
Congestive heart failure |
V-ATPase |
Vacuolar-type H+-ATPase |
CMA |
Chaperone mediated autophagy |
RCAN1 |
Calcineurin |
RYR2 |
Ryanodine receptor 2 |
MEF2D |
Myocyte enhancer factor 2D |
WT |
Wildtype |
hiPSC-CMs |
Cardiomyocytes derived from human induced pluripotent stem cells |
ROS |
Reactive oxygen species |
KO |
Knockout |
Mitophagy |
Mitochondrial autophagy |
S-OPA1 |
Short isoform of optic atrophy 1 |
LC3 |
Microtubule-associated protein light chain 3 |
MEFs |
Mouse embryonic fibroblasts |
STX17 |
Syntaxin 17 |
SNAP29 |
Synaptosome-associated protein 29 |
VAMP8 |
Vesicle-associated membrane protein 8 |
ATG14 |
Autophagy related 14 |
IDUA |
α-L-iduronidase |
AAV9 |
Adeno-associated virus serotype 9 |
FDA |
Food and Drug Administration |