Table 1.

Recent studies on lysosome dysfunction in cardiovascular disease.

Lysosome Function	Lysosomal Component/Pathway	Disease/Models	References
Insufficient	V-ATPase/lysosome acidification	Doxorubicin-induced cardiotoxicity	[28]
	TFEB/biogenesis	cardiac proteinopathy/desmin-related cardiomyopathy	[17]
	LAMP-2B/autophagy	Danon disease	[9]
	TFEB/biogenesis	Myocardial I/R injury	[19]
Excessive	Cathepsin B	Coronary heart disease (CLARICOR trial)	[24]
	Cathepsin B	Mucopolysaccharidosis type I	[25]