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Schematic representation of the potential link of NHE2 to the actin cytoskeleton and subsequently the tight junction through binding partners. The primary candidate protein linking NHE2 to the actin cytoskeleton is phosphorylated ezrin. Based on information known about NHE3 and data from NHE2 in vivo studies, NHE2 may bind directly to ezrin or indirectly through additional binding partners, including NHERF1/EBP50.
