Figure 2.

Schematic representation of the link between ClC-2 and caveolar trafficking of occludin. This schematic is a slight modification from a previously published figure [81] to more closely associate ClC-2 to both the tight junction complex and to caveolin-1-associated endocytosis and recycling of tight junction proteins such as occludin. Note that the representation of ClC-2 at the tight junction complex is not exclusively apical in localization, which leaves room for ClC-2 to be more closely associated with occludin in the membrane.