Figure 2.

Analysis of abnormal platelet miRNA expression induced by sepsis. First, miRNAs were profiled by TaqMan Open Array in three septic and control samples (A). Out of 390 detected, there were 121 significantly downregulated and 61 upregulated miRNAs in septic platelets. Platelet miR-26b (B) was validated in both study groups (n = 21/group), showing attenuated levels in sepsis. Alterations in miRNA expression were further observed in the septic cohort in relation to disease severity (C) and sepsis-related mortality (D). Levels of miR-26b reflected septic shock and early death. Dots represent single expression values. Median values are depicted. Mann–Whitney U test was performed for comparison.