Figure 1.

Workflow from natural product discovery to enzyme utility in accessing complex molecules. The example shown illustrates the chronological order of research on platensimycin (PTM), from molecule discovery [29] to biosynthetic gene cluster (BGC) identification [30] to enzyme characterization [31]. This directly enabled the use of an enzyme from this pathway (PtmO6) in the synthesis of the complex natural products mitrekaurenone, pharboside aglycone, and fujenoic acid [32]. Pink dots represent carbons that are functionalized by PtmO6.