Table 2.
Cell Type | Compound→ | 11c | Phenstatin |
---|---|---|---|
Cell Line↓ | GI50 (μM) b | ||
Leukemia | HL-60(TB) | 2.78 | 0.011 |
SR | 0.807 | <0.010 | |
CCRF-CEM | 3.13 | 0.034 | |
Non-small Cell Lung Cancer |
NCI-H460 | 1.58 | 0.033 |
NCI-H522 | 0.611 | 0.027 | |
HOP-62 | 3.78 | 0.073 | |
Colon Cancer | HCT-116 | 0.619 | 0.038 |
HCT-15 | 1.25 | <0.010 | |
HT29 | 1.42 | 2.95 | |
SW-620 | 0.930 | <0.010 | |
KM12 | 1.30 | <0.010 | |
CNS Cancer | SF-295 | 0.800 | 0.367 |
SF-539 | 2.10 | 0.011 | |
SNB-75 | 2.04 | <0.010 | |
U251 | 3.61 | 0.043 | |
Melanoma | SK-MEL-5 | 0.836 | 0.040 |
M14 | 0.648 | <0.010 | |
MDA-MB-435 | 0.296 | <0.010 | |
UACC-62 | 0.918 | 0.448 | |
LOXIMVI | 2.60 | 0.013 | |
MALME-3M | 1.24 | - | |
SK-MEL-2 | 2.67 | 0.520 | |
SK-MEL-28 | 3.70 | 65.20 | |
Ovarian Cancer | OVCAR-3 | 1.08 | 0.021 |
NCI/ADR-RES | 0.948 | 0.012 | |
IGROV1 | 2.33 | 0.18 | |
OVCAR-8 | 3.73 | 0.042 | |
Renal Cancer | 786-0 | 2.34 | 0.905 |
A498 | 2.82 | 2.28 | |
UO-31 | 0.891 | 0.074 | |
ACHN | 2.40 | 0.042 | |
RXF 393 | 2.06 | 0.016 | |
Breast cancer | MCF7 | 2.25 | 0.033 |
HS 578T | 3.04 | 0.031 | |
MDA-MB-231/ATCC | 2.66 | 0.029 | |
BT-549 | 1.94 | 0.034 | |
T-47D | 2.37 | 30.4 | |
MDA-MB-468 | 2.83 | 2.71 | |
Prostate cancer | PC-3 | 0.960 | 0.045 |
DU-145 | 3.44 | 0.039 |
a Data obtained from NCI’s in vitro 60 cell five-dose screening. b GI50 – the molar concentration of tested compound causing 50% growth inhibition of tumor cells.