Figure 2.

Schematic indicating compounds that oppose the high-glucose-promoted pro-fibrotic actions on cardiac fibroblasts. Intracellular signaling pathways (yellow ovals) are induced in cardiac fibroblasts by high glucose to induce a pro-fibrotic phenotype. Anti-fibrotic compounds (blue rectangles) inhibit various intracellular signaling pathways to oppose the induction of a pro-fibrotic phenotype in cardiac fibroblasts under high glucose conditions.