ECM |
Extracellular matrix |
HFpEF |
Heart failure with preserved ejection fraction |
HG |
High glucose |
α-SMA |
Alpha smooth muscle actin |
ang II |
Angiotensin II |
AT1
|
Angiotensin 1 |
ACE |
Angiotensin-converting enzyme |
TGF-β |
Transforming growth factor beta |
ERK |
Extracellular signal-regulated kinases |
TSP1 |
Thrombospondin 1 |
Akt |
Protein kinase B |
AMPK |
Activation of adenosine monophosphate-activated protein kinase |
PI3 |
Phosphoinositide 3-kinase |
EGF |
Epidermal growth factor |
AGEs |
Advanced glycation end products |
NF-κB |
Nuclear factor kappa B |
RAGE |
Receptor for advanced glycation end products |
IL |
Interleukin |
O-GlcNAc |
O-GlcNAcylation |
HMGB1 |
High-mobility group box 1 |
TLR4 |
Toll-like receptor 4 |
MMP |
Matrix metalloproteinase |
TIMP |
Tissue inhibitor of metalloproteinase |
miRNA |
MicroRNA |
JNK |
c-Jun N-terminal kinase |
MEF2 |
Myocyte enhancer factor 2 |
NO |
Nitric oxide |
iNOS |
Inducible nitric oxide synthase |
H2O2
|
Hydrogen peroxide |
NOD1 |
Nucleotide oligomerization-binding domain 1 |
MeCP2 |
Methyl CpG-binding protein 2 |
RASSF1A |
Ras association domain family 1 isoform A |
PAR-4 |
Protease activated receptor 4 |